Oncovex MGM-CSF –mediated regression of contralateral (non-injected) tumors in the A20 murine lymphoma model does not involve direct viral oncolysis
نویسندگان
چکیده
Background Talimogene laherparepvec (T-VEC) is an injectable modified oncolytic herpes simplex virus type-1 (HSV-1) hypothesized to be efficacious by at least two complimentary mechanisms of action: a) direct oncolysis of the injected tumor and b) elicitation of a systemic antitumor immune response against non-injected lesions and metastases. The purpose of this study was to test that hypothesis that direct viral oncolysis was not involved in the regression of contralateral (non-injected) tumors.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015